Gene Found to Play Role in Macular Degeneration
There has been a significant
association found between advanced AMD and a variant
of the LIPC gene
In May, 2010, at a Fort Lauderdale, Florida
conference of vision research ophthalmologists, it
was announced that a gene had been significantly
linked to advanced
age-related macular degeneration (AMD).
Researcher, ophthalmologist and study author,
Johanna M. Seddon, M.D. said "the finding could lead
to insights regarding (AMD) disease progression."
A variant in the hepatic lipase (LIPC) gene is
involved in encoding triglyceride and
high-density-lipoprotein (HDL) cholesterol function.
LIPC is a critical enzyme in HDL metabolism. And
since the study (and other previous research) shows
that cholesterol biosynthesis could be involved in
AMD, it suggests that people at a genetic risk for
AMD should take measures to control their
cholesterol.
Although there is much more to study in terms of
LIPC's role in cholesterol uptake in the retina, Dr.
Seddon findings seem to echo what The Macula
Center's Dr. Deupree
has been telling his patients for years: Refrain
from smoking, eat dark
green leafy vegetables, eat food rich in
omega-3 fatty acids,
and exercise.
At the very least, the study results demonstrate
that cholesterol biosynthesis may be involved in AMD
and supports data and Dr. Deupree's belief that
cholesterol plays a role in the pathology that leads
to AMD.
Log on to
www.MaculaCenter.com frequently to stay updated
on new retina disease research.
Related Links:
The effects of
antioxidants on the eye and retina
Omega-3 Oils and Retina Health
Retina health vitamins
Ref: Fran Lowry, TMC, 7-2010
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